AI Medical Compendium

Manifold Learning Approaches for Characterizing Photoplethysmographic Signals.

IEEE transactions on bio-medical engineering Jun 1, 2026

OBJECTIVE: Photoplethysmography (PPG) is widely used for cardiovascular monitoring, but its analysis is challenged by signal variability, inconsistent acquisition settings, and limited interpretability. This study investigates the use of low-dimensio... read more

A Hierarchical Multimodal Framework for Sedation Monitoring in ICU Patients.

IEEE transactions on bio-medical engineering Jun 1, 2026

In the intensive care unit (ICU), monitoring sedation levels is crucial. Clinicians often rely on intermittent behavioral scales like the Richmond Agitation-Sedation Scale (RASS), which can be subjective and delay timely interventions. While electroe... read more

From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT

bioRxiv May 31, 2026

Pathologist-annotated tissue regions provide a fundamental reference for examining spatial omics data, yet such annotations are available for a limited number of samples due to the substantial manual effort required. Moreover, these annotations are d... read more

genomics

Instance-Wise Contrastive Graph Neural Network Enables the Discovery of Novel Aedes aegypti Larvicidal Compounds

bioRxiv May 31, 2026

Aedes aegypti remains a major arboviral vector, making larval control a critical strategy to reduce mosquito populations. However, resistance to commercial larvicides has reduced the long-term effectiveness of current interventions, reinforcing the n... read more

bioinformatics

Freezing depth prediction of surrounding rock in seasonally frozen tunnels based on bayes-optimized XGBoost.

Scientific reports May 31, 2026

During freeze-thaw cycles, frost heave forces induced by pore water phase transition in the surrounding rock of seasonally frozen tunnels act continuously on the lining structure, impairing its stability and service performance. The evolution of free... read more

Deep learning-based CT-derived vertebral bone mineral density and metformin therapy: a longitudinal study in the Multi-Ethnic Study of Atherosclerosis.

Skeletal radiology May 31, 2026

OBJECTIVE: Evidence on metformin's skeletal effects remains conflicting. We emulated a target trial to evaluate associations between metformin therapy and deep learning-based CT-derived vertebral bone mineral density (vBMD). We also assessed variatio... read more

Artificial Intelligence Among U.S. Hematology Oncology Fellows: A Multicenter Survey of Education, Attitudes, and Clinical Use.

JCO oncology practice May 31, 2026

PURPOSE: A prior national survey of U.S. hematology/oncology (H/O) fellowship curricula demonstrated substantial heterogeneity and limited protected didactic time. Since then, artificial intelligence (AI), including large language models (LLM) and am... read more

AI-Driven discovery of brain-penetrant mTOR-independent autophagy enhancers for Alzheimer's disease.

Autophagy May 31, 2026

Current Alzheimer's disease therapies offer limited efficacy and are often accompanied by significant side effects, underscoring the urgent need for new treatment strategies. Enhancing autophagy represents a promising therapeutic approach, yet most k... read more

Trends in Computational Metabolomics: A Perspective on Five Years of Software Development, Challenges, and Opportunities (2021-2025).

Analytical chemistry May 31, 2026

Metabolomics software development has accelerated rapidly, yet no recent systematic analysis has quantified how the landscape is evolving across computational methods, geographies, and the research community's technology adoption. There is a strong n... read more

[Artificial intelligence in diabetic retinopathy screening].

Orvosi hetilap May 31, 2026

INTRODUCTION: Visual impairment and blindness continue to represent a substantial disease burden in Hungary. According to national epidemiological data, the combined prevalence of bilateral blindness and severe visual impairment among individuals age... read more

Artificial Intelligence Medical Compendium