AI Medical Compendium

Deep Learning Assisted Motion Behavior Analysis of Catalytic Micromotors Based on Trajectory and Optical Flow.

Nano letters May 31, 2026

Investigating micro/nanomotors' (MNMs') motion behavior is crucial for their practical applications and fundamental understanding of propulsion mechanisms. However, existing methods focus exclusively on a single-drive system and lack discriminative c... read more

Mechanistic Insights into PET-MPs-Aggravated Ischemic Stroke via Integrated Computational-Experimental Approaches.

Environmental science & technology May 31, 2026

Microplastics, especially the environmentally pervasive polyethylene terephthalate microplastics (PET-MPs), are important environmental pollutants, and their potential risks to the health of the nervous system are increasingly a concern. Evidence ind... read more

Integrated Network Pharmacology, Molecular Docking, and Experimental Validation for Uncovering the Pharmacodynamic Basis of Sanghuang against Human Pulmonary Fibrosis.

Combinatorial chemistry & high throughput screening May 31, 2026

INTRODUCTION/OBJECTIVE: Sanghuang, a traditional Chinese medicinal fungus, exhibits well-documented anti-inflammatory, antioxidant, and antitumor activities. Emerging preclinical evidence indicates its efficacy in ameliorating bleomycin-induced Pulmo... read more

Morpho-functional plasticity of tumour-associated macrophages: linking cell shape, ultrastructure, and immune regulation in cancer.

Clinical and experimental medicine May 31, 2026

Macrophages are highly adaptable immune cells that play dual roles in the tumor microenvironment (TME), either promoting or restraining tumor progression. Their polarization into M1 and M2 tumor-associated macrophage (TAM) phenotypes is classically d... read more

From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT

bioRxiv May 31, 2026

Pathologist-annotated tissue regions provide a fundamental reference for examining spatial omics data, yet such annotations are available for a limited number of samples due to the substantial manual effort required. Moreover, these annotations are d... read more

genomics

Instance-Wise Contrastive Graph Neural Network Enables the Discovery of Novel Aedes aegypti Larvicidal Compounds

bioRxiv May 31, 2026

Aedes aegypti remains a major arboviral vector, making larval control a critical strategy to reduce mosquito populations. However, resistance to commercial larvicides has reduced the long-term effectiveness of current interventions, reinforcing the n... read more

bioinformatics

Entropy Fusion DNA: Alignment-Free Gene Fusion Detection through Entropy and Mutual Information Descriptors

bioRxiv May 30, 2026

Gene fusions are clinically relevant genomic alterations and key cancer biomarkers. Their computational detection remains dominated by alignment-based pipelines, whose reliance on read mapping, reference annotations, and heuristic filtering makes the... read more

bioinformatics

Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture

bioRxiv May 30, 2026

The pioneer factor hypothesis posits that specialized transcription factors access nucleosomal DNA to enable binding of secondary factors, implying a hierarchical mechanism of chromatin opening. However, recent evidence indicates that cooperative bin... read more

genomics

Explainable machine learning reveals an RBP regulatory logic of exon skipping

bioRxiv May 30, 2026

RNA binding proteins (RBPs) regulate the life cycle of an mRNA, often through RBP-RNA interactions. This life cycle includes splicing, whereby the intronic sequence of a pre-mRNA is removed and the exons are joined together. However, the patterns of ... read more

systems biology

A pilot assessment of avian communities and soundscapes along an Amazonian fluvial corridor

bioRxiv May 30, 2026

Quantifying biodiversity patterns in remote Amazonian ecosystems remains constrained by the limitations of traditional field surveys. We combined passive acoustic monitoring (PAM), machine learning, and ecoacoustic metrics to assess the taxonomic and... read more

ecology

Artificial Intelligence Medical Compendium

Deep Learning Assisted Motion Behavior Analysis of Catalytic Micromotors Based on Trajectory and Optical Flow.

Mechanistic Insights into PET-MPs-Aggravated Ischemic Stroke via Integrated Computational-Experimental Approaches.

Integrated Network Pharmacology, Molecular Docking, and Experimental Validation for Uncovering the Pharmacodynamic Basis of Sanghuang against Human Pulmonary Fibrosis.

Morpho-functional plasticity of tumour-associated macrophages: linking cell shape, ultrastructure, and immune regulation in cancer.

From unsupervised clustering to atlas-guided annotation in cohort-scale spatial omics with HiCAT

Instance-Wise Contrastive Graph Neural Network Enables the Discovery of Novel Aedes aegypti Larvicidal Compounds

Entropy Fusion DNA: Alignment-Free Gene Fusion Detection through Entropy and Mutual Information Descriptors

Cooperative FOXA1-HNF4A binding emerges from motif spacing and nucleosome architecture

Explainable machine learning reveals an RBP regulatory logic of exon skipping

A pilot assessment of avian communities and soundscapes along an Amazonian fluvial corridor

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