AI Medical Compendium

Substituent-modulated adaptive aromaticity in NHC-pyrrolyl cations: a combined DFT and machine learning study.

Physical chemistry chemical physics : PCCP May 29, 2026

The stabilization of 4π-electron systems remains a fundamental challenge in chemistry, stemming from their intrinsic antiaromaticity and thermodynamic instability as dictated by Hückel's rule. A recent experimental study has demonstrated that rationa... read more

A Reproducible Hierarchical Virtual Screening Framework Integrating Scaffold-Aware Machine Learning, Ensemble Docking, and Molecular Dynamics: Application to IDO1.

Journal of chemical information and modeling May 29, 2026

Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme-containing enzyme implicated in cancer immune escape and remains an attractive therapeutic target despite recent clinical setbacks. We report a fully reproducible hierarchical virtual screening framework... read more

An art-based mixed-methods study exploring children's environmental preferences in home-based nursing research.

Nurse researcher May 29, 2026

BACKGROUND: Evidence-based strategies for designing environments conducive to paediatric clinical research home visits are limited, particularly in low-resource settings. Child-centred methods are needed to support children's environmental preference... read more

Physics-Aware Representation Learning on Electronic Charge Density for Materials Property Prediction.

Journal of chemical information and modeling May 29, 2026

The fundamental quantity governing the mechanical and thermodynamic properties of a crystalline solid is its electronic charge density. Yet, its direct use for the rapid prediction of materials properties remains challenging due to its high dimension... read more

FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression.

Molecular medicine reports May 29, 2026

Hypoxia is a hallmark of oral squamous cell carcinoma (OSCC) and plays a critical role in driving tumor progression. However, the mechanisms by which OSCC cells respond to hypoxic signaling to promote malignant phenotypes remain unclear. The present ... read more

Promise and Practical Limits of Multimodal AI for Cardiac Amyloidosis Detection.

Circulation. Cardiovascular imaging May 29, 2026

Enhydrin from yacon attenuates atherosclerosis by modulating the FABP5/PPARγ/ABCA1 axis: An integrated multi-omics and in vivo validation.

Biochimica et biophysica acta. Molecular and cell biology of lipids May 29, 2026

Dysregulated lipid metabolism drives atherosclerosis (AS). Yacon, an Andean lipid-modulating tuber, exerts anti-AS potential, but mechanisms remain unclear. We integrated network pharmacology, machine learning, single-cell RNA sequencing (scRNA-seq),... read more

UV spectroscopy associated with machine learning as a complementary tool for the diagnosis of Ehrlichia canis in dogs.

Photodiagnosis and photodynamic therapy May 29, 2026

Canine ehrlichiosis, caused by Ehrlichia canis, is a tick-borne disease with a global distribution that significantly affects the clinical and epidemiological landscape for dogs. Although laboratory diagnosis is essential, current diagnostic methods ... read more

External Validation of a mHealth Tool for Detecting Gingival Inflammation in Community-Dwelling Older Adults.

Journal of dentistry May 29, 2026

OBJECTIVE: This study aimed to externally validate the screening performance of a pro-social (equitable, accessible), explainable AI (XAI)-guided mobile health (mHealth) tool, GumAI, that automated the analysis of smartphone photographs to detect sig... read more

Evaluation of two large language models for intensive care unit discharge decisions: a prospective observational cohort study.

Brazilian journal of anesthesiology (Elsevier) May 29, 2026

BACKGROUND: The aim of this study was to evaluate the effectiveness of two general-purpose Large Language Models (LLMs), ChatGPT and Gemini, in predicting Intensive Care Unit (ICU) discharge decisions (discharge vs. non-discharge). By comparing their... read more

Artificial Intelligence Medical Compendium