Bioss: lethal effects of methanolic extract against protoscoleces of .

Journal: Journal of parasitic diseases : official organ of the Indian Society for Parasitology
Published Date: Mar 14, 2015

Abstract

The present study was aimed to evaluate the lethal effects of Boiss (Lamiaceae) methanolic extract against protoscoleces. Protoscoleces were aseptically aspirated from sheep livers having hydatid cysts. Various concentrations of the essential oil (2.5-20 mg/mL) were used for 10-60 min. Viability of protoscoleces was confirmed using eosin exclusion test (0.1 % eosin staining). Obtained results showed that extract at the concentration of 20 mg/mL after 10 min of exposure killed 100 % protoscoleces. The mean of mortality rate of protoscoleces after 20 min of exposure to the concentration of 10 mg/mL was also 100 %. Lower concentrations of extract provoked a delayed protoscolicidal activity. The findings indicated potential of methanolic extract as a natural source for the producing of new scolicidal agent for use in hydatid cyst surgery.

Authors

  • Sareh Jahanbakhsh
    Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
  • Mojgan Azadpour
    Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
  • Amir Tavakoli Kareshk
    Department of Medical Parasitology, Iran University of Medical Sciences, Tehran, Iran.
  • Amir Keyhani
    Department of Medical Parasitology, Jundishapour University of Medical Sciences, Ahvaz, Iran.
  • Hossein Mahmoudvand
    Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.

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