Effects of a natural extract of berry on endothelial cell nitric oxide production.

Journal: Journal of food biochemistry
Published Date: Dec 2, 2015

Abstract

UNLABELLED: The effects of acute and chronic treatment with Aronia extracts on NO production and endothelial nitric oxide synthase (eNOS) phosphorylation in bovine coronary artery endothelial cells were investigated. Acute time-course and concentration-response experiments were performed to determine the time and concentration at which Aronia induced maximal NO synthesis and eNOS phosphorylation. The findings indicate that relatively low concentrations (0.1 μg/mL) of Aronia extract significantly induced NO synthesis and eNOS phosphorylation after 10 min of treatment. Increased sensitivity of eNOS and a significant increase in NO synthesis resulted from longer-term stimulation with Aronia (48 hr) and an acute re-treatment of the cells (10 min).

Authors

  • Claudia Elena Varela
    School of Medicine, University of California San Diego, La Jolla, CA,U.S.A.
  • Emilie Fromentin
    NATUREX DBS LLC., South Hackensack, NJ, U.S.A.
  • Marc Roller
    NATUREX SA., Avignon Cedex 9, France.
  • Francisco Villarreal
    School of Medicine, University of California San Diego, La Jolla, CA,U.S.A.
  • Israel Ramirez-Sanchez
    School of Medicine, University of California San Diego, La Jolla, CA,U.S.A; Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, D.F., Mexico.

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