White adipose tissue cells and the progression of cachexia: inflammatory pathways.

Journal: Journal of cachexia, sarcopenia and muscle
Published Date: Jul 7, 2015

Abstract

BACKGROUND: Cachexia is a systemic syndrome leading to body wasting, systemic inflammation, and to metabolic chaos. It is a progressive condition, and little is known about its dynamics. Detection of the early signs of the disease may lead to the attenuation of the associated symptoms. The white adipose tissue is an organ with endocrine functions, capable of synthesising and secreting a plethora of proteins, including cytokines, chemokines, and adipokines. It is well established that different adipose tissue depots demonstrate heterogeneous responses to physiological and pathological stimuli. The present study aimed at providing insight into adipocyte involvement in inflammation along the progression of cachexia.

Authors

  • Rodrigo X Neves
    Cancer Metabolism Research Group.
  • José Cesar Rosa-Neto
    Immunometabolism Research Group.
  • Alex S Yamashita
    Department of Physiology and Biophysics, Institute of Biomedical Sciences University of São Paulo São Paulo Brazil.
  • Emidio M Matos-Neto
    Cancer Metabolism Research Group.
  • Daniela M R Riccardi
    Cancer Metabolism Research Group.
  • Fábio S Lira
    Exercise and Immunometabolism Research Group, Department of Physical Education, Universidade Estadual Paulista (UNESP), Presidente Prudente, Brazil.
  • Miguel L Batista
    Laboratory of Adipose Tissue Biology, Center for Integrated Biotechnology University of Mogi das Cruzes Mogi das Cruzes Brazil.
  • Marília Seelaender
    Cancer Metabolism Research Group.

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