The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model.

Journal: Frontiers in pharmacology
Published Date: Jan 3, 2025

Abstract

BACKGROUND: Cefoperazone/sulbactam (CPZ/SAM) is an important treatment option for infections caused by multidrug-resistant gram-negative bacteria. However, it is associated with an increased risk of coagulation disorders (CD) and causes severe bleeding in some instances. Early identification of risk factors and prediction of CD related to CPZ/SAM are crucial for prevention and treatment. This study aimed to explore the risk factors and developed a nomogram model for predicting the risk of coagulopathy in patients undergoing CPZ/SAM treatment.

Authors

  • Changjing Xu
    Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Junlong Zhu
    Department of Vascular Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Kun Tu
    School of pharmacy, Southwest Medical University, Luzhou, China.
  • Hui Tang
    Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Xinxin Zhou
    Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Qiuyu Li
    School of pharmacy, Southwest Medical University, Luzhou, China.
  • Kun Chen
    Department of Anesthesiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China.
  • Xuping Yang
    Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Yilan Huang
    Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

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