North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression.

Journal: Journal of ginseng research
Published Date: Jul 18, 2015

Abstract

BACKGROUND: Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest in understanding how exogenous compounds regulate the adipocyte-macrophage crosstalk. An aqueous (AQ) extract of North American (NA) ginseng (Panax quinquefolius) was previously shown to have strong inflammo-regulatory properties in adipocytes. This study examined whether different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.

Authors

  • Jaime Garbett
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
  • Sarah A F Wilson
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
  • Jessica C Ralston
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
  • Anna A De Boer
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
  • Ed M K Lui
    Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
  • David C Wright
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
  • David M Mutch
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.

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