Inhibitory activity of extracts of Hebridean brown seaweeds on lipase activity.
Journal:
Journal of applied phycology
Published Date:
May 26, 2015
Abstract
The effect of three Hebridean brown seaweeds on lipase activity was assessed using a turbidimetric lipase activity assay and an in vitro simulation of the upper digestive tract. The preparations of , , and were tested; whole seaweed homogenate, sodium carbonate extract, and ethanol extracts (pellet and supernatant were tested separately). All extracts showed significant inhibition of lipase, suggesting multiple bioactive agents, potentially including alginates, fucoidans, and polyphenols. Whole homogenate extract of was the most potent inhibitor of Lipase (IC = 0.119 mg mL-1), followed by ethanol supernatant (IC = 0.159 mg mL-1) while ethanol pellet and sodium carbonate extract showed relatively weaker inhibition (IC = 0.360 mg mL-1 and IC = 0.969 mg mL-1 respectively). For and , strongest inhibition occurred with ethanol pellet (IC = 0.238 and 0.228 mg mL, respectively). These inhibitory effects were validated in a model gut system. The data presented herein suggests the use of seaweed as a potential weight management tool is deserving of further investigation.
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