Protective Effects of Thymoquinone against Methotrexate-Induced Germ Cell Apoptosis in Male Mice.

Journal: International journal of fertility & sterility
Published Date: Dec 23, 2015

Abstract

BACKGROUND: Toxic effects of anti-cancer and other drugs on the normal tissues could be reduced by the herbal plants and their fractions. This study investigated the protective effect of thymoquinone (TQ) as a fraction of Nigella sativa on methotrexate (MTX)- induced germ cell apoptosis in male mice.

Authors

  • Fatemeh Sheikhbahaei
    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Mozafar Khazaei
    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Arezou Rabzia
    Fertility and Infertility Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Kamran Mansouri
    Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Ali Ghanbari
    Department of Anatomical Sciences, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, I.R. Iran.

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