Characterization of phenolic compounds and evaluation of anti-diabetic potential in L. seeds: and studies.

Journal: Open life sciences
Published Date: Dec 31, 2024

Abstract

Moroccan L. seeds were investigated for their phenolic profile and antidiabetic potential. Ultra-high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry analysis revealed a rich phenolic composition, including benzoic acid, cannabisin B, genistein, and epicatechin. , the seed extract exhibited potent α-amylase inhibitory activity (half-maximal inhibitory concentration = 25.02 ± 4.03 μg/mL). studies in diabetic rats demonstrated significant hypoglycemic, hypolipidemic, hepatoprotective, and nephroprotective effects. Molecular docking studies further supported these findings, revealing strong interactions between identified phenolic and the α-amylase enzyme. These results highlight the potential of seeds as a natural source of bioactive compounds for diabetes management.

Authors

  • Rafik El-Mernissi
    Bioactive and Environmental Health Laboratory, Faculty of Sciences, Moulay Ismail University, Meknes, B.P. 11201, Morocco.
  • Naoual El Menyiy
    Laboratory of Pharmacology, National Agency for Medicinal and Aromatic Plants, Taounate, 34025, Morocco.
  • Amira Metouekel
    University of Technology of Compiègne, EA 4297 TIMR, 60205 Compiègne Cedex, France.
  • Aziz Zouhri
    Bioactive and Environmental Health Laboratory, Faculty of Sciences, Moulay Ismail University, Meknes, B.P. 11201, Morocco.
  • Yahya El-Mernissi
    Applied Chemistry Research Unit, Faculty of Science and Techniques, Abdelmalek Essaadi University, Al-Hoceima, Tetouan, Morocco.
  • Farhan Siddique
    School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P.R. China.
  • Sumaira Nadeem
    Department of Pharmacy, The Women University, Multan, 60800, Pakistan.
  • Hassan Amhamdi
    Applied Chemistry Research Unit, Faculty of Science and Techniques, Abdelmalek Essaadi University, Al-Hoceima, Tetouan, Morocco.
  • Oualid Abboussi
    Physiology and Physiopathology Team, Faculty of Sciences, Genomic of Human Pathologies Research Centre, Mohammed V University, Rabat, Morocco.
  • Abdulaziz Abdullah Alsahli
    Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Mohammed Bourhia
    Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences, Ibn Zohr University, 80060, Agadir, Morocco.
  • Musaab Dauelbait
    University of Bahr el Ghazal, Freedom Street, Wau, 91113, South Sudan.
  • Gamal A Shazly
    Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
  • Lhoussain Hajji
    Bioactive and Environmental Health Laboratory, Faculty of Sciences, Moulay Ismail University, Meknes, B.P. 11201, Morocco.

Keywords

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