A common genetic variant of fucosyltransferase 2 correlates with serum carcinoembryonic antigen levels and affects cancer screening in patients with primary sclerosing cholangitis.

Journal: United European gastroenterology journal
Published Date: Apr 9, 2015

Abstract

BACKGROUND: Primary sclerosing cholangitis (PSC) patients are at increased risk of biliary tract cancer, and carcinoembryonic antigen (CEA) serum levels might be used for screening.

Authors

  • Andreas Wannhoff
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.
  • Trine Folseraas
    Research Institute for Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet and University of Oslo, Oslo, Norway.
  • Maik Brune
    Department of Internal Medicine I and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany.
  • Christian Rupp
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.
  • Kilian Friedrich
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.
  • Johannes Knierim
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.
  • Karl Heinz Weiss
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
  • Peter Sauer
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany.
  • Christa Flechtenmacher
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
  • Peter Schirmacher
    Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
  • Wolfgang Stremmel
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.
  • Johannes R Hov
    Research Institute of Internal Medicine and Norwegian PSC Research Center, Division of Surgery and Specialized Medicine, Oslo University Hospital, Oslo, Norway.
  • Daniel N Gotthardt
    Department of Internal Medicine IV, University Hospital Heidelberg, Heidelberg, Germany; Liver Cancer Center Heidelberg, University Hospital Heidelberg, Heidelberg, Germany.

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