Extraction and antioxidant activity of flavonoids of Morus nigra.

Journal: International journal of clinical and experimental medicine
Published Date: Dec 15, 2015

Abstract

Morus nigra has a long history of medicinal use in Chinese medicine, but the study on it is limited, the flavonoids are one of the main biological active substances. In this study, the Morus nigra flavonoids were extracted by ultrasonic and antioxidant activities both in vitro and in vivo were measured. The results showed that hydroxyl radicals clearance rate and superoxide radical anion clearance rate in vitro increased with the concentration of the total flavonoids in the range of 0-1.05 mg/mL and the maximum clearance rate was 80.33% and 87.69%, respectively. After mice were treated with flavonoids, the content of malonaldehyde (MDA) in serum and liver decreased; the activities of superoxide dismutase (SOD) in serum and liver, catalase (CAT) in liver and glutathione peroxidase (GSH-PX) in blood and liver increased; Langhans cells increased in spleen. These results revealed that the Morus nigra flavonoids possessed strong antioxidant activity.

Authors

  • Rui-Zhang Feng
    Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin, 644000, China.
  • Qin Wang
    Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China.
  • Wen-Zhi Tong
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Juan Xiong
    Department of Natural Medicine, School of Pharmacy, Fudan University Shanghai 201203 PR China jxiong@fudan.edu.cn jfhu@fudan.edu.cn.
  • Qin Wei
    Collaborative Innovation Center for Green Chemical Manufacturing and Accurate Detection, Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China. Electronic address: sdjndxwq@163.com.
  • Wan-Hai Zhou
    Key Lab of Aromatic Plant Resources Exploitation and Utilization in Sichuan Higher Education, Yibin University Yibin, 644000, China.
  • Zhong-qiong Yin
  • Xiao-Ya Yin
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Li-Ying Wang
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Ya-Qin Chen
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Yong-Hong Lai
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Hong-Yan Huang
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Qiao-Li Luo
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Lu Wang
    Department of Laboratory, Akesu Center of Disease Control and Prevention, Akesu, China.
  • Ren-Yong Jia
    Key laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University Chengdu 611130, China.
  • Xu Song
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Yuan-Feng Zou
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.
  • Li-Xia Li
    Natural Medicine Research Center, College of Veterinary Medicine, Sichuan Agricultural University Chengdu 611130, China.

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