PHARMACOKINETIC EXPOSURE AND VIROLOGIC RESPONSE IN HIV-1 INFECTED PREGNANT WOMEN TREATED WITH LOPINAVIR/RITONAVIR: AIDS CLINICAL TRIALS GROUP PROTOCOL A5153S: A SUBSTUDY TO A5150.

Journal: Jacobs journal of AIDS/HIV
Published Date: May 16, 2015

Abstract

OBJECTIVE: We studied the pharmacokinetics and pharmacodynamics of boosted soft-gel lopinavir/ritonavir to assess if the area under the plasma concentration versus time curve (AUC) is altered in pregnancy and whether changes in AUC impacted HIV-1 control.

Authors

  • Beverly E Sha
    Division of Infectious Diseases, Rush University Medical Center, Chicago, IL USA.
  • Camlin Tierney
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA USA.
  • Xin Sun
    Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA USA.
  • Alice Stek
    Department of Obstetrics and Gynecology, Los Angeles County and University of Southern California Medical Center, Los Angeles, CA USA.
  • Susan E Cohn
    Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL USA.
  • Robert W Coombs
    Departments of Laboratory Medicine and Medicine, University of Washington, Seattle, WA USA.
  • Barbara Bastow
    Social & Scientific Systems, Inc., Silver Spring, MD USA.
  • Francesca T Aweeka
    University of California, San Francisco, San Francisco, CA USA.

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