A brief method for preparation of gintonin-enriched fraction from ginseng.

Journal: Journal of ginseng research
Published Date: Jun 9, 2015

Abstract

BACKGROUND: Ginseng has been used as a tonic for invigoration of the human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin. Gintonin induces [Ca(2+)]i transient in animal cells via lysophosphatidic acid receptor activation. Gintonin-mediated [Ca(2+)]i transient is linked to anti-Alzheimer's activity in transgenic Alzheimer's disease animal model. The previous method for gintonin preparation included multiple steps. The aim of this study is to develop a simple method of gintonin fraction with a high yield.

Authors

  • Sun-Hye Choi
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Seok-Won Jung
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, South Korea.
  • Hyun-Sook Kim
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine and Bio/Molecular Informatics Center, Konkuk University, Seoul, South Korea.
  • Hyeon-Joong Kim
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Byung-Hwan Lee
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
  • Joon Yong Kim
    VMTH, Konkuk University, Seoul, South Korea.
  • Jung-Hyun Kim
    VMTH, Konkuk University, Seoul, South Korea.
  • Sung Hee Hwang
    Department of Pharmaceutical Engineering, Sangji University, Wonju, South Korea.
  • Hyewon Rhim
    Life Science Division, Korea Institute of Science and Technology, Seoul, South Korea.
  • Hyoung-Chun Kim
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, Korea.
  • Seung-Yeol Nah
    Ginsentology Research Laboratory and Department of Physiology, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.

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