Upregulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells.

Journal: Journal of ginseng research
Published Date: Apr 4, 2015

Abstract

BACKGROUND: The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress.

Authors

  • Sokho Kim
    Department of Laboratory Animal Medicine, Chonbuk National University, Jetonju, Korea.
  • Myung-Hoon Oh
    Department of Laboratory Animal Medicine, Chonbuk National University, Jetonju, Korea.
  • Bum-Seok Kim
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Won-Il Kim
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Ho-Seong Cho
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Byoung-Yong Park
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Chul Park
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Gee-Wook Shin
    Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.
  • Jungkee Kwon
    Department of Laboratory Animal Medicine, Chonbuk National University, Jetonju, Korea; Bio-safety Institute, College of Veterinary Medicine, Chonbuk National University, Jeonju, Korea.

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