Inhibitory effects of total saponin from Korean Red Ginseng on [Ca(2+)]i mobilization through phosphorylation of cyclic adenosine monophosphate-dependent protein kinase catalytic subunit and inositol 1,4,5-trisphosphate receptor type I in human platelets.

Journal: Journal of ginseng research
Published Date: Mar 28, 2015

Abstract

BACKGROUND: Intracellular Ca(2+)([Ca(2+)]i) is a platelet aggregation-inducing molecule. Therefore, understanding the inhibitory mechanism of [Ca(2+)]i mobilization is very important to evaluate the antiplatelet effect of a substance. This study was carried out to understand the Ca(2+)-antagonistic effect of total saponin from Korean Red Ginseng (KRG-TS).

Authors

  • Jung-Hae Shin
    Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Inje-ro, Gimhae-si, Gyeongsangnam-do, Korea.
  • Hyuk-Woo Kwon
    Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Inje-ro, Gimhae-si, Gyeongsangnam-do, Korea.
  • Hyun-Jeong Cho
    Department of Biomedical Laboratory Science, College of Medical Science, Konyang University, Gasuwon-dong, Seo-gu, Daejeon, Korea.
  • Man Hee Rhee
    Laboratory of Veterinary Physiology and Signaling, College of Veterinary Medicine, Kyungpook National University, Buk-gu, Daegu, Korea.
  • Hwa-Jin Park
    Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Inje-ro, Gimhae-si, Gyeongsangnam-do, Korea.

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