Modulation of the antibiotic activity against multidrug resistant strains of 4-(phenylsulfonyl) morpholine.

Journal: Saudi journal of biological sciences
Published Date: Feb 10, 2015

Abstract

The compound 4-(Phenylsulfonyl) morpholine belongs to the class of sulfonamides, which are widely used in the treatment of a large number of diseases caused by microorganisms. This compound has a morpholine group, which is also known for its antimicrobial properties. The aim of the present study was to investigate the antimicrobial and modulating activity of 4-(Phenylsulfonyl) morpholine against standard and multi-resistant strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and strains of the fungi Candida albicans, C. tropicalis and C. krusei. Antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC) using the microdilution method. MIC was ⩾1024 μg/mL for all microorganisms. Regarding modulating activity, the most representative effect occurred with the combination of 4-(Phenylsulfonyl) morpholine at a concentration of 128 μg/mL (MIC 1/8) and amikacin against P. aeruginosa 03, with a reduction in MIC from 312.5 to 39.06 μg/mL.

Authors

  • Maria T A Oliveira
    Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
  • Alexandre M R Teixeira
    Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
  • Cícera J M Cassiano
    Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
  • Diniz M Sena
    Universidade Regional do Cariri - URCA, Crato, CE, Brazil.
  • Henrique D M Coutinho
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Irwin R A Menezes
    1 Universidade Regional do Cariri, Crato, Brasil.
  • Fernando G Figueredo
    Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, CE, Brazil.
  • Luiz E Silva
    Setor Litoral - Universidade Federal do Paraná, Matinhos, PR, Brazil.
  • Thiago A Toledo
    Universidade Federal de São Carlos, São Carlos, SP, Brazil.
  • Ricardo R F Bento
    Universidade Federal do Mato Grosso - UFMT, Cuiabá, MT, Brazil.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals