Clomiphene Citrate Effectively Increases Testosterone in Obese, Young, Hypogonadal Men.

Journal: Reproductive system & sexual disorders : current research
Published Date: Nov 13, 2015

Abstract

BACKGROUND: Obesity has been associated with low testosterone (T) in adult males and in pubertal boys. Therapy for hypogonadism with exogenous T may lead to testicular atrophy and later infertility. Only a few studies have demonstrated that the Selective Estrogen Receptor Modulator (SERM) clomiphene citrate (CC), an estrogen receptor antagonist, increases T in obese hypogonadal men while preventing testicular atrophy. No studies to date using CC have been done in younger obese post-pubertal hypogonadal males.

Authors

  • Sachin V Bendre
    Department of Pediatrics, West Virginia University, Charleston Division, USA.
  • Pamela J Murray
    Department of Pediatrics, West Virginia University, Charleston Division, USA.
  • Shehzad Basaria
    Department of Medicine, Aging and Metabolism, Boston, MA, USA.

Keywords

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