Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities.

Journal: Scientia pharmaceutica
Published Date: Oct 15, 2014

Abstract

A library of 600 taxonomically diverse Panamanian plant extracts was screened for DPPH scavenging and UV-B protective activities, and the methanolic extracts of Mosquitoxylum jamaicense, Combretum cacoucia, and Casearia commersionia were submitted to HPLC-based activity profiling. The compounds located in the active time windows were isolated and identified as gallic acid derivatives and flavonoids. Gallic acid methyl ester (3) and digallic acid derivatives (2, 6) showed the highest DPPH scavenging activity (<10 μg/mL), while protocatechuic acid (7) and isoquercitrin (10) exhibited the highest UV-B protective properties.

Authors

  • Niels Guldbrandsen
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
  • Maria De Mieri
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.
  • Mahabir Gupta
    CIFLORPAN, College of Pharmacy, University of Panama, Apartado 0824-00172, Panama, Republic of Panama.
  • Eleni Liakou
    Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
  • Harris Pratsinis
    Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
  • Dimitris Kletsas
    Laboratory of Cell Proliferation & Ageing, Institute of Biosciences & Applications, NCSR "Demokritos", 15310, Athens, Greece.
  • Eliza Chaita
    Korres S.A. Natural Products, 57th Athens-Lamia National Road, 32011, Inofyta, Greece; Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
  • Nektarios Aligiannis
    Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
  • Alexios-Leandros Skaltsounis
    Department of Pharmacognosy & Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Zografou, 15771, Greece.
  • Matthias Hamburger
    Division of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 40, CH-4056 Basel, Switzerland.

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