Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification.

Journal: Journal of virus eradication
Published Date:

Abstract

BACKGROUND: It is unclear whether intensification of standard highly active antiretroviral therapy (HAART) with entry and integrase inhibitors during acute HIV infection (AHI) could yield greater benefits in reducing markers for HIV reservoir size and immune activation.

Authors

  • Jintanat Ananworanich
    HIV Netherlands Australia Thailand (HIV-NAT) Research Collaboration, Thai Red Cross AIDS Research Center, Bangkok, Thailand; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Nicolas Chomont
    Vaccine and Gene Therapy Institute-Florida, Port St Lucie, FL, USA; Department of Microbiology, Infectiology and Immunology, Université de Montréal, Faculty of Medicine, and Centre de Recherche du CHUM, Montréal, Quebec, Canada.
  • James Lk Fletcher
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Suteeraporn Pinyakorn
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; US Military HIV Research Program, Bethesda, MD, USA.
  • Alexandra Schuetz
    Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA; Armed Forces Research Institute of Medical Sciences, US Component, Bangkok, Thailand.
  • Irini Sereti
    National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
  • Rungsun Rerknimitr
    Division of Gastroenterology, Department of Medicine, Faculty of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Bangkok Thailand.
  • Robin Dewar
    Leidos Biomedical Research Inc, Virus Isolation and Serology Laboratory, Frederick, MD, USA.
  • Eugene Kroon
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Claire Vandergeeten
    Vaccine and Gene Therapy Institute-Florida, Port St Lucie, FL, USA.
  • Rapee Trichavaroj
    Armed Forces Research Institute of Medical Sciences, US Component, Bangkok, Thailand.
  • Nitiya Chomchey
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Thep Chalermchai
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
  • Nelson L Michael
    US Military HIV Research Program, Bethesda, MD, USA; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Jerome H Kim
    US Military HIV Research Program, Bethesda, MD, USA; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Praphan Phanuphak
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand; Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
  • Nittaya Phanuphak
    SEARCH, Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

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