Decreased Intra- and Inter-Salience Network Functional Connectivity is Related to Trait Anxiety in Adolescents.

Journal: Frontiers in behavioral neuroscience
Published Date: Jan 21, 2016

Abstract

OBJECTIVE: Adolescence is a critical period for the vulnerability of anxiety. Imaging studies focusing on adolescents' susceptibility to anxiety suggest that the different development trajectories between the limbic system and the executive control system may play important roles in this phenomenon. However, few studies have explored the brain basis of this susceptibility from the perspective of functional networks. The salience network (SN) consists of a series of key limbic and prefrontal regions that are engaged in the development of anxiety, such as the amygdala, anterior insula (AI), and dorsal anterior cingulate cortex (dACC). Intra- and inter-network connections in this system play essential roles in bottom-up attention and top-down regulation of anxiety, nevertheless, little is known about whether the SN-centered connections are associated with trait anxiety (i.e., susceptibility to anxiety) in adolescents.

Authors

  • Haiyang Geng
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of SciencesBeijing, China; State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal UniversityBeijing, China.
  • Xuebing Li
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
  • Jie Chen
    School of Basic Medical Sciences, Health Science Center, Ningbo University, Ningbo, China.
  • Xinying Li
    Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences Beijing, China.
  • Ruolei Gu
    Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences Beijing, China.

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