Supersaturated state of diazepam injection following dilution with infusion fluid.

Journal: Journal of pharmaceutical health care and sciences
Published Date: Mar 9, 2015

Abstract

BACKGROUND: Significant precipitation produced by the dilution of diazepam (DZP) injection with an infusion fluid is a great concern for the clinical practice. In this study, the precipitation behavior under different conditions was investigated.

Authors

  • Yoshinori Onuki
    Department of Pharmaceutics, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Naoki Hasegawa
    Department of Pharmaceutics, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Chihiro Kida
    Department of Pharmaceutics, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Mayumi Ikegami-Kawai
    Central Research Laboratories, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Masayoshi Tsubuki
    Central Research Laboratories, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Shunsuke Shirozu
    Division of Applied Pharmaceutical Education and Research, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Yasuko Obata
    Department of Pharmaceutics, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.
  • Kozo Takayama
    Department of Pharmaceutics, Hoshi University, 2-4-41 Ebara, Shinagawa, Tokyo 142-8501 Japan.

Keywords

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