Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.

Journal: Journal of geriatric cardiology : JGC
Published Date: Nov 1, 2015

Abstract

BACKGROUND: The induced pluripotent stem cell (iPSC) has shown great potential in cellular therapy of myocardial infarction (MI), while its application is hampered by the low efficiency of cardiomyocyte differentiation. The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on cardiomyocyte differentiation from mouse induced pluripotent stem cells (miPSCs) and the underlying mechanisms involved.

Authors

  • Tong Liu
    Intensive Care Medical Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200065, People's Republic of China.
  • Ran Zhang
    Jiangsu Province Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China.
  • Tao Guo
    Key Laboratory of Digital Technology in Medical Diagnostics of Zhejiang Province, Hangzhou, Zhejiang, China.
  • Sai Ma
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Dong Han
    Department of Radiology, Affiliated Hospital of Chengde Medical College, Chengde Hebei, 067000, P.R.China.
  • Xiu-Juan Li
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Yan Jin
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA.
  • Miao-Miao Fan
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
  • Ya-Bin Wang
    Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
  • Yun-Dai Chen
    Department of Cardiology, Chinese PLA General Hospital, Beijing, China.
  • Feng Cao
    Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China; Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

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