Advanced whole transcriptome sequencing and artificial intelligence/machine learning (AI/ML) in imiquimod-induced psoriasis-like inflammation of human keratinocytes.

Journal: BioMedicine
Published Date: Dec 1, 2024

Abstract

INTRODUCTION: Although the HaCaT keratinocyte model has been used in previous research to study the effects of antipsoriatic agents, there is still a lack of comprehensive understanding of the mechanism of imiquimod (IMQ)-induced proliferation and signal transduction in psoriasis-like keratinocytes.

Authors

  • Lii-Tzu Wu
    Department of Microbiology, School of Medicine, China Medical University, Taichung, Taiwan.
  • Shih-Chang Tsai
    Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
  • Tsung-Jung Ho
    Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Hao-Ping Chen
    Integration Center of Traditional Chinese and Modern Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
  • Yu-Jen Chiu
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Yan-Ru Peng
    Department of Ophthalmology, Taipei City Hospital, Taipei, Taiwan.
  • Ting-Yuan Liu
    Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.
  • Yu-Ning Juan
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Jai-Sing Yang
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Fuu-Jen Tsai
    Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

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