Integrating natural product research laboratory with artificial intelligence: Advancements and breakthroughs in traditional medicine.

Journal: BioMedicine
Published Date: Dec 1, 2024

Abstract

The Natural Product Research Laboratory (NPRL) of China Medical University Hospital (CMUH) was established in collaboration with CMUH and Professor Kuo-Hsiung Lee from the University of North Carolina at Chapel Hill. The laboratory collection features over 6000 natural products worldwide, including pure compounds and semi-synthetic derivatives. This is the most comprehensive and fully operational natural product database in Taiwan. This review article explores the history and development of the NPRL of CMUH. We then provide an overview of the recent applications and impact of artificial intelligence (AI) in new drug discovery. Finally, we examine advanced powerful AI-tools and related software to explain how these resources can be utilized in research on large-scale drug data libraries. This article presents a drug research and development (R&D) platform that combines AI with the NPRL. We believe that this approach will reduce resource wastage and enhance the research capabilities of Taiwan's academic and industrial sectors in biotechnology and pharmaceuticals.

Authors

  • Jai-Sing Yang
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Shih-Chang Tsai
    Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
  • Yuan-Man Hsu
    Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.
  • Da-Tian Bau
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Chia-Wen Tsai
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Wen-Shin Chang
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Sheng-Chu Kuo
    Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.
  • Chien-Chih Yu
    School of Pharmacy, College of Pharmacy, China Medical University, Taichung, Taiwan.
  • Yu-Jen Chiu
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan.
  • Fuu-Jen Tsai
    Million-Person Precision Medicine Initiative, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

Keywords

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