Cigarette smoke condensate and individual constituents modulate DNA methyltransferase expression in human liver cells.
Journal:
SAGE open medicine
Published Date:
Apr 22, 2015
Abstract
OBJECTIVES: Previous studies found higher expression levels of DNA methyltransferase 1 in liver samples from smokers compared to those from non-smokers. In contrast, expression levels of DNA methyltransferase 3a and DNA methyltransferase 3b were similar in smokers and non-smokers. This study extends these studies to establish a causal linkage to cigarette smoke exposure by examining whether DNA methyltransferase expression is modulated by cigarette smoke condensate.
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