Cerium oxide nanoparticle aggregates affect stress response and function in Caenorhabditis elegans.

Journal: SAGE open medicine
Published Date: Mar 19, 2015

Abstract

OBJECTIVE: The continual increase in production and disposal of nanomaterials raises concerns regarding the safety of nanoparticles on the environmental and human health. Recent studies suggest that cerium oxide (CeO2) nanoparticles may possess both harmful and beneficial effects on biological processes. The primary objective of this study is to evaluate how exposure to different concentrations (0.17-17.21 µg/mL) of aggregated CeO2 nanoparticles affects indices of whole animal stress and survivability in Caenorhabditis elegans.

Authors

  • Steven Rogers
    Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA.
  • Kevin M Rice
    Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA.
  • Nandini Dpk Manne
    Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA.
  • Tolou Shokuhfar
    Department of Mechanical Engineering and Engineering Mechanics, Michigan Technological University, Houghton, MI, USA.
  • Kun He
    1 Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University , Chongqing, China .
  • Vellaisamy Selvaraj
    Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA.
  • Eric R Blough
    Center for Diagnostic Nanosystems, Marshall University, Huntington, WV, USA; Department of Pharmaceutical Sciences and Research, Marshall University, Huntington, WV, USA.

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