From Genome to Phenome: Opportunities and Challenges of Molecular Imaging.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Published Date: May 8, 2025

Abstract

The study of the human phenome is essential for understanding the complexities of wellness and disease and their transitions, with molecular imaging being a vital tool in this exploration. Molecular imaging embodies the 4 principles of human phenomics: precise measurement, accurate calculation or analysis, well-controlled manipulation or intervention, and innovative invention or creation. Its application has significantly enhanced the precision, individualization, and effectiveness of medical interventions. This article provides an overview of molecular imaging's technologic advancements and presents the potential use of molecular imaging in human phenomics and precision medicine. The integration of molecular imaging with multiomics data and artificial intelligence has the potential to transform health care, promoting proactive and preventive strategies. This evolving approach promises to deepen our understanding of the human phenome, lead to preclinical diagnostics and treatments, and establish quantitative frameworks for precision health management.

Authors

  • Mei Tian
    Huashan Hospital and Human Phenome Institute, Fudan University, Shanghai, China; tianmei@fudan.edu.cn hzhang21@zju.edu.cn.
  • Leroy Hood
    Institute for Systems Biology, Seattle, Washington.
  • Arturo Chiti
    Vita-Salute San Raffaele University, Milan, Italy.
  • Markus Schwaiger
    School of Medicine and Health, Technical University of Munich, Munich, Germany.
  • Satoshi Minoshima
    Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, Utah.
  • Yasuyoshi Watanabe
    Osaka City University Center for Health Science Innovation, Osaka, Japan.
  • Keon Wook Kang
    Seoul National University Hospital, Seoul, Republic of Korea.
  • Hong Zhang
    Department of Anesthesiology and Operation, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

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