Inhibition of the polyol pathway by extract: plausible implications for diabetic retinopathy treatment.

Journal: Frontiers in pharmacology
Published Date: Dec 23, 2024

Abstract

INTRODUCTION: Diabetic retinopathy is a significant microvascular disorder and the leading cause of vision impairment in working-age individuals. Hyperglycemia triggers retinal damage through mechanisms such as the polyol pathway and the accumulation of advanced glycation end products (AGEs). Inhibiting key enzymes in this pathway, aldose reductase (AR) and sorbitol dehydrogenase (SD), alongside preventing AGE formation, may offer therapeutic strategies for diabetic retinopathy and other vascular complications. This study investigates the ability of , an Arabian plant, to inhibit AR and SD enzymes.

Authors

  • Saheem Ahmad
    Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
  • Mohammad Faizan Ali Ahmad
    Department of Biosciences, Integral University, Lucknow, India.
  • Saif Khan
    Department of Basic Dental and Medical Sciences, College of Dentistry, University of Hail, Hail, Saudi Arabia.
  • Sultan Alouffi
    Department of Medical Laboratory Sciences, College of Applied Medical Sciences, University of Hail, Hail, Saudi Arabia.
  • Mahvish Khan
    Department of Biology, College of Science, University of Hail, Hail, Saudi Arabia.
  • Mohd Wajid Ali Khan
    Department of Chemistry, College of Science, University of Hail, Hail, Saudi Arabia.
  • Irfan Ahmad Ansari
    Department of Biosciences, Integral University, Lucknow, India.

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