Artificial Intelligence Measured Tumor Burden and Pre-Treatment Circulating Tumor DNA in Human Papilloma Virus-Associated Oropharynx Cancer.

Journal: Head & neck
Published Date: May 5, 2025

Abstract

BACKGROUND: Artificial intelligence (AI)-based imaging analysis and circulating tumor-associated DNA (ctDNA) are both being used diagnostically in HPV-driven oropharynx squamous cell carcinoma (HPV-OPSCC). We evaluated associations between AI-measured tumor burden and ctDNA.

Authors

  • Mina Bakhtiar
    Harvard Radiation Oncology Program, Brigham & Women's Hospital and Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Zezhong Ye
    Artificial Intelligence in Medicine (AIM) Program, Harvard Medical School, Boston, Massachusetts, USA.
  • Jonathan D Schoenfeld
    Department of Radiation Oncology, Brigham & Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Homan Mohammadi
    Department of Radiation Oncology, Mayo Clinic Jacksonville, Jacksonville, Florida, USA.
  • Jeffrey P Guenette
    Division of Neuroradiology, Brigham & Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Eleni M Rettig
    Department of Head and Neck Surgery, Brigham & Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Glenn J Hanna
    Department of Head and Neck Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA.
  • Benjamin H Kann
    Artificial Intelligence in Medicine (AIM) Program, Harvard Medical School, Boston, Massachusetts, USA.

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