Liver fibrosis progression analyzed with AI predicts renal decline.

Journal: JHEP reports : innovation in hepatology
Published Date: Feb 12, 2025

Abstract

BACKGROUND & AIMS: The relationship between biopsy-proven liver fibrosis progression and renal function decline in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) has not been fully elucidated. We used an automated quantitative liver fibrosis assessment (qFibrosis) technique to investigate the temporal changes in regional liver fibrosis.

Authors

  • Dan-Qin Sun
    Department of Nephrology, Jiangnan University Medical Center, Wuxi, China.
  • Jia-Qi Shen
    Department of Nephrology, Jiangnan University Medical Center, Wuxi, China.
  • Xiao-Fei Tong
    Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Capital Medical University, Beijing, China.
  • Ya-Yun Ren
    HistoIndex Pte Ltd, Singapore.
  • Hai-Yang Yuan
    MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Yang-Yang Li
    Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Xin-Lei Wang
    HistoIndex Pte Ltd, Singapore.
  • Sui-Dan Chen
    Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Pei-Wu Zhu
    MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Xiao-Dong Wang
    Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province, Wenzhou, China.
  • Christopher D Byrne
    Southampton National Institute for Health and Care Research Biomedical Research Centre, University Hospital Southampton and University of Southampton, Southampton General Hospital, Southampton, UK.
  • Giovanni Targher
    Department of Medicine, University of Verona, Verona, Italy.
  • Lai Wei
  • Vincent W S Wong
    Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong Special Administrative Region of China.
  • Dean Tai
    HistoIndex Pte Ltd, Singapore.
  • Arun J Sanyal
    Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
  • Hong You
    Liver Research Center, Beijing Friendship Hospital, Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis, National Clinical Research Center of Digestive Diseases, Capital Medical University, Beijing, China.
  • Ming-Hua Zheng
    MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Keywords

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