Impact of type 2 diabetes mellitus on apical periodontitis size, endotoxin levels and bacterial load in root canals with necrotic pulp.

Journal: Journal of endodontics
Published Date: May 9, 2025

Abstract

INTRODUCTION: This clinical study was conducted to describe the endodontic microbiological profile of teeth with apical periodontitis in patients with type 2 diabetes mellitus (T2DM), focusing on bacterial count and endotoxin levels found in primary infection, as well as the size of periapical lesions, determined by cone-beam computed tomography (CBCT) analysis.

Authors

  • Mirela Cesar de Barros
    Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Evelyn Giuliana Velasquez-Espedilla
    Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Luciane Dias de Oliveira
    Department of Biosciences and Oral Diagnosis, São Paulo State University, Institute of Science and Technology, São José dos Campos, São Paulo, Brazil.
  • Brenda Paula F A Gomes
    Department of Restorative Dentistry, Division of Endodontics, Piracicaba School of Dentistry, State University of Campinas, Piracicaba, São Paulo, Brazil.
  • Marco Antônio Hungaro Duarte
    Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.
  • Carlos Antônio Negrato
    Bauru School of Medicine, University of São Paulo, Bauru, São Paulo, Brazil.
  • Flaviana Bombarda de Andrade
    Department of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil. Electronic address: flaviana@fob.usp.br.

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