Inadequate imipenem dosing in patients with decreased kidney function: A clinical pharmacokinetic study.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Published Date: May 9, 2025

Abstract

OBJECTIVES: A number of population pharmacokinetic (popPK) models of imipenem in critically ill patients are available for dosing optimisation, but they represent only a narrow range of kidney functions. This study evaluates the target attainment of on-label regimens through popPK modelling and simulation in patients across different kidney functions.

Authors

  • Anh Quan Truong
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands; National Drug Information and Adverse Drug Reaction Monitoring Centre, Hanoi University of Pharmacy, Hanoi, Vietnam.
  • Tim J L Smeets
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands.
  • Jean Terrier
    Division of General Internal Medicine, Geneva University Hospitals, Geneva, Switzerland; Clinical Pharmacology and Toxicology Service, Anesthesiology Pharmacology and Intensive Care Department, Geneva University Hospitals, Geneva, Switzerland.
  • Letao Li
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands.
  • Xuan Co Dao
    Intensive Care Unit, Bach Mai Hospital, Hanoi, Vietnam.
  • Jan Strojil
    Department of Pharmacology, Palacky University, Czech Republic.
  • Tim Preijers
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands.
  • Birgit C P Koch
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands.
  • Angela Huttner
    Division of Infectious Diseases, Geneva University Hospitals, Faculty of Medicine, Geneva, Switzerland.
  • Sebastiaan D T Sassen
    Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands; Rotterdam Clinical Pharmacometrics Group, Rotterdam, The Netherlands. Electronic address: s.sassen@erasmusmc.nl.

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