PSMA MRI Guided Prostate SABR ARGOS-CLIMBER Phase I/II Trial: A Primary Endpoint Analysis.

Journal: International journal of radiation oncology, biology, physics
Published Date: May 9, 2025

Abstract

PURPOSE: The XXXXX trial is a multi-institutional phase I/II study utilizing a combined PSMA PET/MRI approach to treat dominant intraprostatic lesions (DILs) and affected lymph nodes in unfavorable intermediate and high-risk prostate cancer using a five fraction SABR and simultaneous in-field boost (SIB) technique. Here we report on the primary endpoint of toxicity within 6 months of treatment.

Authors

  • Sherif Ramadan
    Department of Oncology, Division of Radiation Oncology, London Health Sciences Centre and Western University, London, ON, Canada.
  • Andrew Loblaw
    Department of Radiation Oncology, Odette Cancer Center, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
  • Aneesh Dhar
    Department of Oncology, Division of Radiation Oncology, London Health Sciences Centre and Western University, London, ON, Canada.
  • Hatim Fakir
    Department of Oncology and Department of Medical Biophysics, London Health Sciences Centre and Western University, London, ON, Canada.
  • Lucas C Mendez
    Department of Oncology, Division of Radiation Oncology, London Health Sciences Centre and Western University, London, ON, Canada.
  • Andrew Warner
    Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada.
  • Matt Wronski
    Department of Medical Biophysics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  • John Conyngham
    Patient Partner, London, ON, Canada.
  • Zahra Kassam
    Department of Medical Imaging, St. Joseph's Health Care and Western University, London, ON, Canada.
  • Vibhuti Kalia
    Department of Medical Imaging, St. Joseph's Health Care and Western University, London, ON, Canada.
  • Vivian S Tan
    Department of Oncology, Division of Radiation Oncology, London Health Sciences Centre and Western University, London, ON, Canada.
  • Priscila Crivellaro
    Department of Medical Imaging, St. Joseph's Health Care and Western University, London, ON, Canada.
  • Aaron D Ward
    Department of Medical Biophysics, Western University and Lawson Health Research Institute, London, ON, Canada.
  • Jonathan Thiessen
    Department of Medical Biophysics, Western University and Lawson Health Research Institute, London, ON, Canada.
  • Ting-Yim Lee
    Department of Medical Biophysics, Western University and Lawson Health Research Institute, London, ON, Canada.
  • David Laidley
    Division of Nuclear Medicine, St. Joseph's Health Centre and Western University, London, ON, Canada.
  • Glenn S Bauman
    Department of Oncology, Division of Radiation Oncology, London Health Sciences Centre and Western University, London, ON, Canada. Electronic address: glenn.bauman@lhsc.on.ca.

Keywords

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