Simultaneous initiation of dolutegravir-based antiretroviral therapy and once-weekly rifapentine and isoniazid for tuberculosis prevention in antiretroviral-naive people with HIV: an open-label, non-randomised, phase 1/2 trial.

Journal: The lancet. HIV
Published Date:

Abstract

BACKGROUND: Tuberculosis preventive treatment with 3 months of once-weekly isoniazid (900 mg) and rifapentine (900 mg; 3HP) is a recommended option for people with HIV; among adults with virological suppression, the 3HP regimen given with dolutegravir-based antiretroviral therapy (ART) is safe and maintained virological suppression. The DOLPHIN-TOO study assessed safety, dolutegravir pharmacokinetics, and virological efficacy of concurrent initiation of dolutegravir-based ART and 3HP among antiretroviral-naive adults with HIV.

Authors

  • Ethel D Weld
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Johns Hopkins University School of Medicine Center for Tuberculosis Research, Baltimore, MD, USA. Electronic address: eweld@jhmi.edu.
  • Trevor Beattie
    The Aurum Institute, Parktown, South Africa; Department of Interdisciplinary Social Sciences, Utrecht University, Utrecht, Netherlands.
  • Jayajothi Moodley
    The Aurum Institute, Parktown, South Africa; Department of Interdisciplinary Social Sciences, Utrecht University, Utrecht, Netherlands.
  • Manasa Mapendere
    The Aurum Institute, Parktown, South Africa.
  • Isadora Salles
    The Johns Hopkins University School of Medicine Center for Tuberculosis Research, Baltimore, MD, USA.
  • BelĂ©n P Solans
    University of California San Francisco School of Medicine, San Francisco, CA, USA.
  • Bareng A S Nonyane
    The Johns Hopkins University School of Medicine Center for Tuberculosis Research, Baltimore, MD, USA; The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Lubbe Wiesner
    Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
  • Tanya Nielson
    The Aurum Institute, Parktown, South Africa; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Vinodh A Edward
    The Aurum Institute, Parktown, South Africa; Department of Interdisciplinary Social Sciences, Utrecht University, Utrecht, Netherlands; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; School of Health Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
  • Violet Chihota
    The Aurum Institute, Parktown, South Africa; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.
  • Radojka M Savic
    University of California San Francisco School of Medicine, San Francisco, CA, USA.
  • Kelly E Dooley
    Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Richard E Chaisson
    The Johns Hopkins University School of Medicine, Baltimore, MD, USA; The Johns Hopkins University School of Medicine Center for Tuberculosis Research, Baltimore, MD, USA; The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Gavin J Churchyard
    The Aurum Institute, Parktown, South Africa; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; School of Public Health, University of the Witwatersrand, Johannesburg, South Africa.

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