Preoperative BOLD cerebrovascular reactivity correlates with intraoperative STA-MCA bypass flow and influences postoperative CVR improvement.

Journal: European stroke journal
Published Date: May 10, 2025

Abstract

INTRODUCTION: The superficial temporal artery-middle cerebral artery (STA-MCA) flow augmentation bypass is effective for treating Moyamoya vasculopathy and selected cases of atherosclerotic large vessel disease. Recently, blood oxygen level-dependent cerebrovascular reactivity (BOLD-CVR) has emerged as a novel tool to assess hemodynamic impairment for patient selection and monitoring. This study investigates whether preoperative BOLD-CVR in the affected vascular territory (i.e. middle cerebral artery (MCA) territory) correlates with intraoperative bypass flow and whether intraoperative bypass flow serves as a predictor of postoperative hemodynamic improvement.

Authors

  • Martina Sebök
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Vittorio Stumpo
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Jacopo Bellomo
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Giuseppe Esposito
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Christiaan Hendrik Bas van Niftrik
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Zsolt Kulcsár
    Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
  • Andreas R Luft
    Clinical Neuroscience Center, University Hospital Zurich, Zurich, Switzerland.
  • Luca Regli
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Jorn Fierstra
    Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

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