Seizures influence sleep macrostructure and the sleep-wake circadian rhythm in Dravet syndrome.

Journal: Epilepsia
Published Date: May 10, 2025

Abstract

OBJECTIVE: Dravet syndrome (DS) is a developmental and epileptic encephalopathy with a wide spectrum of comorbidities comprising sleep disorders, reported in up to 85% of cases. For this, a sleep study is recommended in patients with a sleep complaint. However, no data are available on sleep architecture in DS or on the impact of seizures on sleep quality and macrostructure. We aim to investigate the impact of epileptic phenomena on sleep in DS.

Authors

  • Alberto Cossu
    Child Neuropsychiatry Unit, Department of Children and Maternal Health, AOUI Verona, full member of European Reference Network EpiCARE, Verona, Italy.
  • Jacopo Proietti
    Child Neuropsychiatry Unit, Department of Children and Maternal Health, AOUI Verona, full member of European Reference Network EpiCARE, Verona, Italy.
  • Ludovica Ghobert
    Child Neuropsychiatry Unit, Department of Children and Maternal Health, AOUI Verona, full member of European Reference Network EpiCARE, Verona, Italy.
  • Livia Rinaldi
    Department of Innovation Medicine and Engineering, University of Verona, Verona, Italy.
  • Bernardo Dalla Bernardina
    Research Center for Pediatric Epilepsies, Department of Children and Maternal Health, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
  • Francesca Darra
    Child Neuropsychiatry Unit, Department of Children and Maternal Health, AOUI Verona, full member of European Reference Network EpiCARE, Verona, Italy.
  • Gaetano Cantalupo
    Child Neuropsychiatry Unit, Department of Children and Maternal Health, AOUI Verona, full member of European Reference Network EpiCARE, Verona, Italy.

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