Preoperative radiomics models using CT and MRI for microsatellite instability in colorectal cancer: a systematic review and meta-analysis.

Journal: Abdominal radiology (New York)
Published Date: May 10, 2025

Abstract

OBJECTIVE: Microsatellite instability (MSI) is a novel predictive biomarker for chemotherapy and immunotherapy response, as well as prognostic indicator in colorectal cancer (CRC). The current standard for MSI identification is polymerase chain reaction (PCR) testing or the immunohistochemical analysis of tumor biopsy samples. However, tumor heterogeneity and procedure complications pose challenges to these techniques. CT and MRI-based radiomics models offer a promising non-invasive approach for this purpose.

Authors

  • Gianluca Capello Ingold
    Hospital Universitario Austral, Buenos Aires, Argentina. gianluca.capello@gmail.com.
  • João Martins da Fonseca
    Hospital Geral de Salvador, Salvador (BA), Brazil.
  • Sanda Kolenda Zloić
    Special Hospital Agram, Zagreb, Croatia.
  • Sarah Verdan Moreira
    Hospital of the Federal University of Juiz de Fora, Minas Gerais, Brazil.
  • Karabo Kago Marole
    St. George's University, St. George's, Grenada.
  • Emma Finnegan
    Trinity College Dublin, Dublin, Ireland.
  • Marcia Harumy Yoshikawa
    Brigham and Women's Hospital, Boston, USA.
  • Silvija Daugėlaitė
    Radviliškis Hospital, Lithuania, Lithuania.
  • Tábata Xavit Souza E Silva
    Beneficência Portuguesa de São Paulo, São Paulo, Brazil.
  • Marco Aurélio Soato Ratti
    Fleury Group, São Paulo, Brazil.

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