Accurate prediction of virulence factors using pre-train protein language model and ensemble learning.

Journal: BMC genomics
Published Date:

Abstract

BACKGROUND: As bacterial pathogens develop increasing resistance to antibiotics, strategies targeting virulence factors (VFs) have emerged as a promising and effective approach for treating bacterial infections. Existing methods mainly relied on sequence similarity, and remote homology relationships cannot be discovered by sequence analysis alone.

Authors

  • Guanghui Li
    State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.
  • Jian Zhou
    CTIQ, Canon Medical Research USA, Inc., Vernon Hills, 60061, USA.
  • Jiawei Luo
  • Cheng Liang