Serum Interleukin-6 Exhibits Better Diagnostic Performance Than Serum C-Reactive Protein in Acute Periprosthetic Joint Infection.

Journal: The Journal of arthroplasty
Published Date: May 7, 2025

Abstract

BACKGROUND: Inflammatory biomarkers serve as the first-line screening tools for diagnosing periprosthetic joint infection (PJI). However, the kinetics and trajectory of each biomarker in response to inflammatory stimuli vary. This study aimed to identify the most reliable diagnostic predictors for acute and chronic PJI through a comprehensive evaluation of the diagnostic accuracy of commonly utilized serum biomarkers.

Authors

  • Xiaohui Zhang
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China.
  • Fan Lü
    Institute of Waste Treatment & Reclamation, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China.
  • Baolin Zhang
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China.
  • Zhongcheng Liu
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China.
  • Bin Geng
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China.
  • Hua Han
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China.
  • Yayi Xia
    Department of Orthopaedic Surgery, the Second Hospital &Clinical Medical School, Lanzhou University, Lanzhou, Gansu Province, China. Electronic address: xiayayilzu@sina.com.

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