Effect of glycerin on colonic motility in children.

Journal: Journal of pediatric gastroenterology and nutrition
Published Date: May 8, 2025

Abstract

OBJECTIVE: Colonic manometry (CM) involves measurement of colonic neuromuscular activity and administration of a stimulant laxative, most commonly bisacodyl, which is part of the study protocol. Glycerin is another laxative used in the treatment of constipation. Our objective was to evaluate the effect of glycerin on colonic motility and compare the response to glycerin with each patient's response to bisacodyl.

Authors

  • Julia M J van der Zande
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Anna E Leone
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Shruthi Srinivas
    Department of Colorectal and Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Richard J Wood
    Department of Colorectal and Pelvic Reconstructive Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Marc A Benninga
    Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Academic Medical Centre, Amsterdam, The Netherlands.
  • Raul E Sanchez
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Neetu Bali Puri
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Karla Vaz
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Desale Yacob
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Carlo Di Lorenzo
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
  • Peter L Lu
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.

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