Mesenchymal stem cell transplantation ameliorates inflammation in spinal cord injury by inhibiting lactylation-related genes.

Journal: Cytokine
Published Date: May 8, 2025

Abstract

BACKGROUND: The immune microenvironment significantly influences neural regeneration in spinal cord injury (SCI). Lactate activates central nervous system (CNS) glial cells, prompting the secretion of proinflammatory cytokines and triggering an inflammatory response. Mesenchymal stem cells (MSCs) make a promising future for SCI therapy due to their immune regulation and anti-inflammatory properties. However, it is unclear whether MSCs inhibit inflammatory responses in the SCI microenvironment through lactylation regulation. This study aimed to identify lactylation-related genes (LRGs) in SCI and investigate their role in immune cell infiltration and MSC-mediated inflammation reduction.

Authors

  • Weiwei Zou
    Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Zelin Zhang
    College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
  • Tingting Cao
    Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
  • Mangmang Li
    Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China. Electronic address: mangmangli@smu.edu.cn.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals