A yak bone collagen-derived antioxidant peptide with excellent stability alleviates UVA-induced photoaging by activating the Keap1/Nrf2 signaling pathway.

Journal: Journal of the science of food and agriculture
Published Date: May 9, 2025

Abstract

BACKGROUND: Prolonged exposure to ultraviolet A (UVA) rays can trigger oxidative stress, leading to skin photoaging. Our team previously identified four antioxidant peptides derived from yak bone collagen through bioinformatics prediction. The objective of this study was to screen out one most promising application antioxidant peptide through molecular docking, in vitro antioxidant activity verification and stability assessment, and elucidate its mechanism of action.

Authors

  • Zijun Wang
    School of Chemistry and Chemical Engineering, Shihezi University Shihezi Xinjiang 832003 PR China eavanh@163.com lqridge@163.com 1175828694@qq.com 318798309@qq.com wzj_tea@shzu.edu.cn.
  • Pengfei Xu
    Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.
  • Bo Hu
    Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
  • Zhenghua Gu
    Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.
  • Yu Xin
    Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.
  • Zhongpeng Guo
    Engineering Research Center for Cereal Fermentation and Food Biomanufacturing, School of Biotechnology, Jiangnan University, Wuxi, China.
  • Dake Dong
    Department of Dermatology, Affiliated Hospital of Jiangnan University, Wuxi, China.
  • Zitao Guo
    School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China.
  • Liang Zhang

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