Discovery of novel benzoxazinone derivatives as promising protoporphyrinogen IX oxidase inhibitors.

Journal: Pest management science
Published Date: May 9, 2025

Abstract

BACKGROUND: Protoporphyrinogen IX oxidase (PPO, EC 1.3.3.4) has emerged as a key target for developing new herbicides to protect crops from weeds. Herein, we disclose the development of two types of PPO inhibitors by modification of the benzoxazinone skeleton.

Authors

  • Hui Cai
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
  • Xiao Zhang
    Merck & Co., Inc., Rahway, NJ, USA.
  • Dan Ling
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
  • Meng Zhang
    College of Software, Beihang University, Beijing, China.
  • Chen Pang
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
  • Shi-Chao Ren
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
  • Zhichao Jin
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.
  • Yonggui Robin Chi
    State Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China.

Keywords

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