Identifying Common Disease Trajectories of Progressive Supranuclear Palsy with Electronic Health Records.

Journal: Movement disorders clinical practice
Published Date: May 9, 2025

Abstract

BACKGROUND: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder characterized by parkinsonism and impairments in balance, language, and cognition. As an atypical parkinsonism, PSP progresses rapidly, lacks effective treatments, and poses significant caregiving burdens. While prior studies have identified risk factors, they often fail to capture the complex temporal dynamics of co-occurring conditions.

Authors

  • Mingzhou Fu
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Sriram Sankararaman
    Computational Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Keith A Vossel
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
  • Timothy S Chang
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.

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