Impact of tracer uptake rate on quantification accuracy of myocardial blood flow in PET: A simulation study.

Journal: Medical physics
Published Date: May 8, 2025

Abstract

BACKGROUND: Cardiac perfusion PET is commonly used to assess ischemia and cardiovascular risk, which enables quantitative measurements of myocardial blood flow (MBF) through kinetic modeling. However, the estimation of kinetic parameters is challenging due to the noisy nature of short dynamic frames and limited sample data points.

Authors

  • Xiaotong Hong
    School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
  • Amirhossein Sanaat
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
  • Yazdan Salimi
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
  • RenĂ© Nkoulou
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, Geneva, Switzerland.
  • Hossein Arabi
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211, Geneva 4, Switzerland.
  • Lijun Lu
    School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
  • Habib Zaidi
    Division of Nuclear Medicine and Molecular Imaging, Geneva University Hospital, CH-1211, Geneva 4, Switzerland. habib.zaidi@hcuge.ch.

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