Evaluation of the Efficacy of Step-down Therapy with Oral Minocycline for Complicated Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Retrospective Cohort Study.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Published Date: May 6, 2025

Abstract

BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections present significant treatment challenges owing to limited oral antibiotic options. Minocycline is active against ESBL-E; however, its efficacy remains unclear. This study evaluated the efficacy of step-down therapy using oral minocycline for complicated pyelonephritis (cPN) caused by ESBL-producing Escherichia coli.

Authors

  • Ryota Ito
    Department of Pharmacy, Tohoku Rosai Hospital, Sendai 981-8563, Japan. Electronic address: ryota.ito712@gmail.com.
  • Takashi Watanabe
    Division of Clinical Pharmaceutics and Pharmacy Practice, Tohoku Medical and Pharmaceutical University, Sendai 983-8536, Japan; Division of Clinical Pharmacotherapeutics, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan; Department of Pharmacy, Tohoku Medical and Pharmaceutical University Hospital, Sendai 983-8512, Japan.
  • Yuta Hoshino
    Department of Pharmacy, Tohoku Rosai Hospital, Sendai 981-8563, Japan.
  • Kenichi Takahashi
    Tohoku Rosai Hospital, Sendai, Japan.

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