Shared and Distinctive Inflammation-Related Protein Profiling in Idiopathic Inflammatory Myopathy with/without Anti-MDA5 Autoantibodies.

Journal: Journal of inflammation research
Published Date: May 7, 2025

Abstract

PURPOSE: Due to the heterogeneous nature of the diseases, treatment efficacy and prognosis vary for idiopathic inflammatory myopathy (IIM) patients with different myositis specific autoantibodies (MSAs). This study aimed to investigate the inflammation-related protein profiling of IIM patients with different MSAs. In addition, the shared and distinctive inflammation-related protein profiling in IIM with/without anti-MDA5 autoantibodies.

Authors

  • Yusheng Zhang
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Wenlu Hu
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Tianqi Li
    College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of the Provincial Education, Department of Heilongjiang for Common Animal Disease Prevention and Treatment, Northeast Agricultural University, Harbin 150030, China.
  • Zhou Pan
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Jinlei Sun
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Yujie He
    Department of Computer Science and Engineering, Washington University, St. Louis, MO.
  • Wenjuan Guan
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Lijuan Zhang
    School of Computer Science and Engineering, Changchun University of Technology, Jilin 130012, China.
  • Chaofeng Lian
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Shengyun Liu
    Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.
  • Panpan Zhang
    School of Information Science and Technology, Northwest University, Xi'an, China.

Keywords

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