Targeting Metabolic Reprogramming in Bladder Cancer Immunotherapy: A Precision Medicine Approach.

Journal: Biomedicines
Published Date: May 9, 2025

Abstract

Bladder cancer, as a highly heterogeneous malignant tumor of the urinary system, is significantly affected by tumor metabolic reprogramming in its response to immunotherapy. This review systematically elaborates on the molecular mechanisms of abnormal glucose and lipid metabolism in the bladder cancer microenvironment and immune escape, and discusses precision treatment strategies based on metabolic regulation. In the future, it will be necessary to combine spatiotemporal omics and artificial intelligence technologies to construct a multi-target intervention system for the metabolic-immune interaction network, promoting a paradigm shift in precision treatment for bladder cancer.

Authors

  • Fuyang Liu
    College of Environmental Sciences and Engineering, Peking University, Beijing 100871, P. R. China.
  • Kai Li
    Department of Gastroenterology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
  • Qingyi Zhu
    Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, 121 Jiangjia Yuan, Nanjing, Jiangsu, 210003, China. Electronic address: drzhuqingy@126.com.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals